In June 1778, a 700 wagon caravan escorted the Liberty Bell on its return to Philadelphia from Allentown along Towamencin's Allentown Road. Nine months earlier, when British troops threatened to capture the city, the bell had been whisked into hiding via the same route.

Originally Bellefonte, a town now with a population of 5,000, was once considered to be Pennsylvania's capital. But Harrisburg was chosen because of the easy navigation on the Susquehanna River.

The Liberty Tunnel in Pittsburgh opened in 1924. At that time the 5,700 foot facility was the longest artificially ventilated automobile tunnel in the world.

Drake Well Museum in Titusville is on the site where Edwin L. Drake drilled the world's first oil well in 1859 and launched the modern petroleum industry.

Pennsylvania is the first state of the fifty United States to list their web site URL on a license plate.